Figure 2 |. Characterization of the different rates of cystic kidney disease progression in Pkd1^RC/RC mice in various genetic backgrounds.

(a) Percent kidney weight/body weight (KW/BW), (b) percent cystic area, (c) cyst number, (d) percent fibrotic area, and (e) blood urea nitrogen (BUN) were determined in mice from each background that were killed at 1, 3, 6, 9, and 12 months (see Table 1 for group sizes). The mean ± SD are shown on each scatter plot. Change in cystic disease within each background compared to the 1-month baseline was performed using a 1-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison test within each genetic background: *P < 0.05, **P < 0.01, ***P < 0.001. In addition, each time point in each background was compared to corresponding B6 mice to determine differences in cystic disease by using a 2-way ANOVA followed by Dunnett’s multiple comparison test: ^†P < 0.05, ^††P < 0.01, ^†††P < 0.001. Where possible, the same animals were measured for each endpoint but not all groups had equal numbers of male and female mice (Table 1; see Figure 3 and Supplementary Tables S1 and S2 for sex-specific data). B6, C57BL/6J; BC, BALB/cJ; 129, 129S6/SvEvTac.