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Effects of beta-globin mutations on rHb functionality
| Alpha-globin | rHb | Beta-globin | Oxygen binding affinity (P50) | Cooperativity (nMax) |
|---|---|---|---|---|
| Di | rHb0.1 | Wild type | 10 | 2.2 |
| rHb9.1 | Lys-82→Asp | 15 | 2.0 | |
| rHb1.1 | Asn-108→Lys | 31 | 2.4 | |
| rHb9+1.1 | Asn-108→Lys + | 44 | 2.2 | |
| Lys-82→Asp | ||||
| Mono | rHb0.0 | Wild type | 15 | 2.6 |
| rHb1.0 | Asn-108→Lys | 36 | 2.5 |
