Table 2.
Association between knee injury and knee pain, overall and by joint hypermobility status.
| Genetics of Generalized OA (GOGO) |
Genetics of OA (GO) |
Johnston County OA Project (JoCoOA) |
||||
|---|---|---|---|---|---|---|
| Total Sample | N = 2341 | N = 1872 | N = 1987 | |||
| Prior Knee Injury | No Prior Knee Injury | Prior Knee Injury | No Prior Knee Injury | Prior Knee Injury | No Prior Knee Injury | |
| 249 (10.6%) | 2092 (89.4%) | 192 (10.3%) | 1680 (89.7%) | 323 (16.3%) | 1664 (83.7%) | |
| Knee Pain, n (%) | 206 (82.7) | 1335 (63.8) | 99 (51.6) | 511 (30.4) | 229 (70.9) | 660 (39.7) |
| aORa (95% CI) |
2.67 (1.87–3.80) |
2.51 (1.83–3.45) |
3.75 (2.85–4.94) |
|||
|
By Joint Hypermobility Status | ||||||
|
Beighton ≥ 4 |
N = 78 |
N = 197 |
N = 138 |
|||
| Prior Knee Injury | No Prior Knee Injury | Prior Knee Injury | No Prior Knee Injury | Prior Knee Injury | No Prior Knee Injury | |
| 11 (14.1%) | 67 (85.9%) | 11 (5.6%) | 186 (94.4%) | 22 (16.3%) | 116 (83.7%) | |
| Knee Pain, n (%) | 10 (90.9) | 29 (43.3) | 5 (45.5) | 48 (25.8) | 14 (63.6) | 42 (36.2) |
| aORa (95% CI) | 5.05 (0.67–38.2) | 3.48 (0.99–12.25) | 3.10 (1.13–8.48) | |||
|
Beighton < 4 |
N = 2263 | N = 1675 | N = 1849 | |||
| Prior Knee Injury | No Prior Knee Injury | Prior Knee Injury | No Prior Knee Injury | Prior Knee Injury | No Prior Knee Injury | |
| 238 (10.5%) | 2025 (89.4%) | 181 (10.8%) | 1494 (89.2%) | 301 (16.3%) | 1548 (83.7%) | |
| Knee Pain, n (%) | 196 (82.4) | 1306 (64.5) | 93 (51.4) | 463 (31.0) | 215 (71.4) | 618 (39.9) |
| aORa (95% CI) | 2.48 (1.73–3.54) | 2.41 (1.75–3.33) | 3.83 (2.87–5.11) | |||
| p-value for interactionb | 0.105 | 0.580 | 0.813 | |||
OA = osteoarthritis, aOR = adjusted odds ratio, CI = confidence interval.
a
Adjusted for age, gender, and body mass index; additional adjustment for race in the Johnston County OA Project and for family membership in the Genetics of Generalized OA study.
b
Interaction between prior knee injury and joint hypermobility in relation to knee pain.