Table 3.
Association between knee injury and knee radiographic OA, overall and by joint hypermobility status.
| Genetics of Generalized OA (GOGO) |
Genetics of OA (GO) |
Johnston County OA Project (JoCoOA) |
||||
|---|---|---|---|---|---|---|
| Total Sample | N = 2341 | N = 1872 | N = 1987 | |||
| Prior Knee Injury 249 (10.6%) |
No Prior Knee Injury 2092 (89.4%) |
Prior Knee Injury 192 (10.3%) |
No Prior Knee Injury 1680 (89.7%) |
Prior Knee Injury 323 (16.3%) |
No Prior Knee Injury 1664 (83.7%) |
|
| Knee rOA, n (%) | 160 (64.3) | 828 (39.6) | 101 (52.6) | 489 (29.1) | 142 (44.0) | 624 (37.5) |
| aORa (95% CI) |
2.82 (2.12–3.76) |
2.54 (1.82–3.55) |
1.83 (1.38–2.42) |
|||
| By Joint Hypermobility Status | ||||||
|
Beighton ≥ 4 |
N = 78 |
N = 197 |
N = 138 |
|||
| Prior Knee Injury 11 (14.1%) |
No Prior Knee Injury 67 (85.9%) |
Prior Knee Injury 11 (5.6%) |
No Prior Knee Injury 186 (94.4%) |
Prior Knee Injury 22 (16.3%) |
No Prior Knee Injury 116 (83.7%) |
|
| Knee rOA, n (%) | 9 (81.8) | 20 (29.9) | 3 (27.3) | 43 (23.1) | 6 (27.3) | 32 (27.6) |
| aORa (95% CI) | 11.02 (4.03–30.1) | 0.81 (0.19–3.42) | 1.89 (0.54–6.63) | |||
| Beighton < 4 | N = 2263 | N = 1675 | N = 1849 | |||
| Prior Knee Injury 238 (10.5%) |
No Prior Knee Injury 2025 (89.4%) |
Prior Knee Injury 181 (10.8%) |
No Prior Knee Injury 1494 (89.2%) |
Prior Knee Injury 301 (16.3%) |
No Prior Knee Injury 1548 (83.7%) |
|
| Knee rOA, n (%) | 151 (63.4) | 808 (39.9) | 98 (54.1) | 446 (29.9) | 136 (45.2) | 592 (38.2) |
| aORa (95% CI) | 2.67 (1.99–3.58) | 2.91 (2.09–4.06) | 1.83 (1.38–2.45) | |||
| p-value for interactionb | 0.009 | 0.090 | 0.866 | |||
OA = osteoarthritis, rOA = radiographic osteoarthritis, aOR = adjusted odds ratio, CI = confidence interval.
a
Adjusted for age, gender, and body mass index; additional adjustment for race in the Johnston County OA Project and for family membership in the Genetics of Generalized OA study.
b
Interaction between prior knee injury and joint hypermobility in relation to knee rOA.