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. Author manuscript; available in PMC: 2022 May 14.
Published in final edited form as: Curr Top Dev Biol. 2019 Feb 6;132:1–29. doi: 10.1016/bs.ctdb.2019.01.001

Figure 4. Progenitors at different time points give rise to both overlapping and distinct subsets of cells.

Figure 4.

A simplified model depicting key features of developmental hematopoiesis. Around E7, cells of the yolk sac blood islands give rise to primitive macrophages and to primitive erythrocytes that are nucleated and express fetal globins. At E8.5, EMPs contribute to the first wave of tissue resident macrophages, including microglia in the developing brain. By E10.5, the first engraftable HSCs emerge in the AGM region of the embryo proper and initiate production of traditional mature blood cells (erythrocytes, platelets, granulocytes, monocytes/macrophages, B cells, T cells, and NK cells. At E14.5, developmentally restricted (dr)HSCs and persisting HSCs coexist in the fetal liver; drHSCs efficiently produce innate-like and traditional lymphoid cells. After birth, definitive HSCs primarily reside in the bone marrow and contribute to ”traditional” mature blood cells for the lifespan of the animal.