Table 4.

Geometric mean and 95% confidence intervals (95% CI) of the omeprazole hydroxylation index during baseline, CYP2C19 inhibition with fluconazole, and during induction with rifampicin in 20 healthy study participants

	100 µg omeprazole		20 mg omeprazole
	Geometric mean	95% CI	Geometric mean	95% CI
Baseline
All (n = 20)	1.26	0.75–2.12	2.47	1.71–3.57
UM (n = 7)	0.92	0.35–2.41	2.0	1.04–3.84
EM (n = 6)	1.20	0.48–3.0	2.34	1.16–4.7
IM (n = 6)	1.18	0.46–3.0	2.31	1.28–4.18
PM (n = 1)	22.8		21.7
Fluconazole
All (n = 20)	49.3*	39.6–61.4	28.7*	23.5–35.0
UM (n = 7)	41.0	25.2–66.9	21.8	14.3–33.4
EM (n = 6)	58.4	34.9–97.6	29.8	20.6–43.3
IM (n = 6)	49.2	32.1–75.3	36.6	27.9–48.0
PM (n = 1)	65.1		44.0
Rifampicin
All (n = 20)	0.55	0.37–0.82	0.50*	0.33–0.74
UM (n = 7)	0.41	0.19–0.87	0.32	0.20–0.51
EM (n = 6)	0.51	0.34–0.79	0.55	0.28–1.08
IM (n = 6)	0.54	0.29–1.04	0.47	0.25–0.89
PM (n = 1)	3.70		5.46

*Test all participants baseline vs. fluconazole or rifampicin: p < 0.05