Table 1.
Demographic, clinical, and neuroimaging data of sample
| HC (n = 110) |
svPPA (n = 34) |
nfvPPA (n = 34) |
|
|---|---|---|---|
| Demographic and clinical data | |||
| Age at exam (years)a | 63.12 ± 7.49 | 62.91 ± 6.29 | 68.32 ± 7.27 |
| Gender (M/F) | 49/61 | 20/14 | 15/19 |
| Education (years) | 17.50 ± 1.92 | 16.94 ± 3.09 | 16.51 ± 3.39 |
| MMSEb | 29.35 ± 0.77 | 24.97 ± 5.10 | 25.54 ± 4.04 |
| CDR Total score | – | 0.63 ± 0.31 | 0.48 ± 0.40 |
| CDR-SOB scorec | – | 3.40 ± 1.72 | 2.15 ± 2.11 |
| Semantic Fluency (animal)b | 24.25 ± 5.53 | 9.03 ± 4.15 | 10.72 ± 6.01 |
| Lexical Fluency (phonemic)b,c | 16.37 ± 4.34 | 8.97 ± 4.47 | 5.53 ± 3.35 |
| BNT (max = 15)b,c | 14.46 ± 0.78 | 5.90 ± 3.42 | 12.64 ± 2.28 |
| Neuroimaging data | |||
| Intracanial Volume (ml) | 1517.69 ± 69.04 | 1535.34 ± 156.76 | 1471.09 ± 171.17 |
MMSE: Mini-Mental State Examination; CDR Total: Clinical Dementia Rating Total score; CDR-SOB: Clinical Dementia Rating: Box Score; BNT: Boston Naming Test; HC: healthy controls; svPPA: patients with semantic variant of primary progressive aphasia; nfvPPA: patients with nonfluent variant of primary progressive aphasia
ap < 0.05 nfvPPA patients versus controls and svPPA patients
bp < 0.05 svPPA and nfvPPA patients versus controls
cp < 0.05 svPPA patients versus nfvPPA patients