Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 30;143(6):697–711. doi: 10.1007/s00401-022-02424-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — DNA methylation profiling of ATRT–SHH reveals three distinct molecular subgroups. Unsupervised t-SNE analysis of the tumor cases together with > 83.000 samples of the molecularneuropathology.org data set (a) segregates ATRT–SHH into three DNA methylation subgroups. A more focused analysis of the ATRT cases within the Heidelberg data set (n = 1919) further suggests the presence of three ATRT–SHH subgroups (b). Black dots indicate the cases of this study. Unsupervised clustering analysis using spherical k-means clustering for k = 2–6 revealed most stable consensus heatmaps and membership partitioning for k = 3 clusters (c)