Table 2.
PBMC phenotypes and correlations with mtDNA TVN
| Subset percentage of total PBMC | ||
|---|---|---|
| CD3+CD4+ | CD3+CD8+ | |
| Patients (n = 16) | 33.9 (8.03) | 23.1 (9.38) |
| Donors (n = 10) | 44.8 (7.01) | 21.5 (3.43) |
| Subtype percentage of PBMC subset | |||
|---|---|---|---|
| CD3+CD4+ Ki67+ |
CD3+CD8+ Granzyme B+ |
CD3+CD8+ Perforin+ |
|
| Patients (n = 16) | 1.39 (1.33) | 41.4 (25.7) | 18.5 (14.6) |
| Donors (n = 10) | 1.49 (0.68)a | 18.8 (12.3) | 10.7 (6.38) |
| Correlation between mtDNA TVN and the PBMC subtype numberb | ||||||
|---|---|---|---|---|---|---|
| rho | p | rho | p | rho | p | |
| Patients (n = 16) | 0.734 | 0.001 | 0.534 | 0.033 | 0.590 | 0.016 |
| Donors (n = 10) | 0.687 | 0.033 | ||||
PBMC numbers are given by mean (standard deviation)
mtDNA mitochondrial DNA, PBMC peripheral blood mononuclear cell, TVN total variant number
aNot normally distributed
bStatistically significant correlations with mtDNA TVN are shown, by Spearman correlation test