Table 1.

Summary of structural and biochemical features of patient-derived pathogenic tau, α-syn and TDP-43

^aCTF C-terminal fragment

^bPrP-CAA with mutation Q160X in the PRNP gene

^cGSS with mutation F198S in the PRNP gene

^dPDB protein data bank ID number

^eHMW high-molecular-weight

^fCTF at 23 kDa is the most intense band in Type A

^gCTF at 24 kDa is the most intense band in Type B