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. 2022 May 14;79(6):295. doi: 10.1007/s00018-022-04262-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — POSTN is associated with lymphatic vessels. Morphometric analysis of experimental (pre)-metastatic LNs as described in Fig. 2. a–d–g Colocalization analysis of POSTN (red) and LYVE1 (green) at PM (at 1 week in A and at 2 weeks in d) and M (at 4 weeks in g) stages. Bars = 50 µm and 10 µm in the right (higher magnification of the insert) images. b–e–h Scatter graphs use scatter plots to represent POSTN-LYVE1 colocalization densities (in percentage) (n ≥ 7). Results are expressed as mean ± SD (Wilcoxon–Mann–Whitney test: *p < 0.05; **p < 0.01; ***p < 0.001). c–f–i Spatial distribution analysis from tissue edge to tissue center. The blue rectangle delineates the area between 0–0.30 mm from the LN border where the cumulate normalized area of LYVE1 and POSTN were measured and represented in the top right. Maximum distance of migration from the tissue border (Lmax) is indicated. Results are expressed as mean ± SD (Wilcoxon–Mann–Whitney test: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001)