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. 2022 May 14;13(5):460. doi: 10.1038/s41419-022-04900-y

Fig. 4. The structure of IAP family members.

Fig. 4

IAP members all have at least one baculoviral IAP repeat (BIR) domain that facilitates their interaction with other proteins. Some IAPs contain a Really Interesting New Gene (RING) domain that mediates E3 ligase activity. cIAP1/2 additionally contains a CAspase Recruitment Domain (CARD) which functions in protein-protein interactions.