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. 2022 May 14;12:8008. doi: 10.1038/s41598-022-11760-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation analysis between UBE2C and clinical markers and evaluation of combined diagnostic effect. (A, D, G) The correlation between UBE2C and clinical markers (BRCA1, KI67 and TP53) in esophageal cancer was analyzed by GEPIA database. R represents the correlation coefficient. (B, E, H) Expression of clinical markers (BRCA1, KI67 and TP53) in esophageal cancer. The brown part represents the target protein. (C, F, I) The correlation between UBE2C and clinical markers (BRCA1, KI67 and TP53) was analyzed according to the results of clinical immunohistochemistry. (J-L) ROC curve was used to analyze the diagnostic efficacy of clinical markers (BRCA1, KI67 and TP53) in esophageal cancer. (M) Efficacy of UBE2C combined with clinical markers (BRCA1, KI67 and TP53) in the diagnosis of esophageal cancer.