Table 4. Effect of Therapeutic Strategies on the Blood-Brain Barrier in AD Models.

Table 4 lists studies indicated in Figure 6 that show the effects of therapeutics strategies in transgenic AD mice and rats. References: (Batarseh, et al., 2017; Batarseh & Kaddoumi, 2018; Beckmann, Gerard, Abramowski, Cannet, & Staufenbiel, 2011; Bien-Ly, et al., 2015; Blockx, et al., 2016; Burbach, et al., 2007; Burgess, Dubey, et al., 2014; Burgess, Nhan, Moffatt, Klibanov, & Hynynen, 2014; Chauhan & Sandoval, 2007; Chauhan, Siegel, & Lichtor, 2004; J. J. Choi, et al., 2008; Cortes-Canteli, et al., 2019; Dubey, et al., 2020; Elfakhri, et al., 2019; Fan, DeFilippis, & Van Nostrand, 2007; Faraco, et al., 2016; Fitz, et al., 2014; Hattori, et al., 2016; Herring, et al., 2010; Hur, et al., 2018; Jordao, et al., 2010; Jordao, et al., 2013; Kook, et al., 2014; Lazic, et al., 2019; W. J. Lee, et al., 2020; Leinenga & Gotz, 2018; Leinenga, Koh, & Gotz, 2019; M. Liu, et al., 2018; X. Liu, et al., 2019a, 2019b; Lynch, et al., 2021; Marinescu, et al., 2017; Michael, et al., 2019; Mueggler, et al., 2003; Nyul-Toth, et al., 2020; Ongali, et al., 2014; Pandit & Mukhopadhyay, 2004; Y. H. Park, et al., 2020; Passos, Kilday, Gillen, Cribbs, & Vasilevko, 2016; Poduslo, Curran, Wengenack, Malester, & Duff, 2001; Poon, Pellow, & Hynynen, 2021; Reuter, Venus, Grudzenski, et al., 2016; Robison, et al., 2020; Royea, Martinot, & Hamel, 2020; Saito, Buciak, Yang, & Pardridge, 1995; Schultheiss, et al., 2006; Shabir, et al., 2020; Sharp, et al., 2019; J. Song, Choi, Whitcomb, & Kim, 2017; St-Amour, et al., 2013; Takeda, et al., 2009; Thakker, et al., 2009; Uekawa, et al., 2016; Van Skike, et al., 2018; Vasilevko, Xu, Previti, Van Nostrand, & Cribbs, 2007; Weber-Adrian, et al., 2019; Xhima, et al., 2020; Xie, et al., 2020; Xiong, et al., 2021; M. Xu, et al., 2020; J. Yan, et al., 2015; P. Yan, et al., 2015).

# In Fig. 6	Therapeutic Strategy	Model	Reference
1	Angiotensin Receptor Blockers	Tg2576 Mice	Nyül-Töth et al. 2020; Passos et al. 2016; Faraco et al. 2016
2	Angiotensin Receptor Blockers	APP23 Mice	Takeda et al. 2009
3	Angiotensin Receptor Blockers	hAPP (J20) Mice	Ongali et al. 2014; Royea et al. 2020
4	Angiotensin Receptor Blockers	TgSwDI Mice	Faraco et al. 2016
5	Angiotensin Receptor Blockers	5xFAD Mice	Uekawa et al. 2016
6	Antibiotics	Tg2576 Mice hAPP (J20) Mice	Yan et al. 2015
7	Antibiotics	Tg2576 Mice hAPP (J20) Mice	Van Skike et al. 2018
8	Antibiotics	TgSwDI Mice	Fan et al. 2007
9	Antibiotics	5xFAD Mice	Yan et al. 2015
10	Anticoagulants	Tg2576 Mice	Micheal et al. 2019
11	Anticoagulants	APP23 Mice	Marinescu et al. 2017
12	Anticoagulants	TgCRND8 Mice	Cortes-Canteli et al. 2019
13	Anticoagulants	5xFAD Mice	Lazic et al. 2019
14	Antioxidants	Tg2576 Mice	Park et al. 2020; Han et al. 2015
15	Antioxidants	APP23 Mice	Liu et al. 2019a; Liu et al. 2019b
16	Antioxidants	TgSwDI Mice	Saito et al. 2017
17	Antioxidants	APP/PS1 Mice	Xu et al 2020
18	Antioxidants	5xFAD Mice	Elfakhri et al 2019; Batarseh & Kaddoumi, 2018; Song et al. 2017; Batarseh et al. 2017; Kook et al. 2014
19	Cranial / Cognitive Stimulations	APP23 Mice	Mueggler et al. 2003
20	Cranial / Cognitive Stimulations	hAPP (J20) Mice	Shabir et al. 2020; Sharp et al. 2019
21	Cranial / Cognitive Stimulations	TgCRND8 Mice	Herring et al. 2010
22	Cranial / Cognitive Stimulations	TgSwDI Mice	Robison et al. 2020
23	Immunosuppressants	hAPP (J20) Mice	Van Skike et al. 2018
24	Passive Immunotherapies	PDAPP Mice	Blockx et al. 2016
25	Passive Immunotherapies	Tg2576 Mice	Thakker et al. 2009
26	Passive Immunotherapies	APP23 Mice	Burbach et al. 2007; Fitz et al. 2014; Beckmann et al. 2011
27	Passive Immunotherapies	TgCRND8 Mice	Dubey et al. 2020; Jordäo et al. 2010; Chauhan, 2007; Chauhan et al. 2004
28	Passive Immunotherapies	TgSwDI Mice	Vasilevko et al. 2007
29	Passive Immunotherapies	3xTg-AD	St-Amour et al. 2013
30	Passive Immunotherapies	Tau P301L Mice	Bien-Ly et al. 2015
31	Passive Immunotherapies	APP/PS1 Mice	Podulso et al. 2001
32	Passive Immunotherapies	5xFAD Mice	Xiong et al. 2021
33	Scanning / Focused Ultrasound	APP23 Mice	Leinenga et al. 2019; Leinenga & Götz, 2018 Poon et al. 2021; Lynch et al. 2021; Dubey et al. 2020
34	Scanning / Focused Ultrasound	TgCRND8 Mice	Liu et al. 2018; Burgess et al. 2014a; Burgess et al. 2014b; Jordäo et al. 2013; Jordäo et al. 2010; Xhima et al. 2020; Weber-Adrian et al. 2019;
35	Scanning / Focused Ultrasound	Tau P301L Mice	Pandit et al. 2019
36	Scanning / Focused Ultrasound	APP/PS1 Mice	Choi et al 2008
37	Scanning / Focused Ultrasound	5xFAD Mice	Lee et al. 2020
38	Short-Chain Fatty Acids	Tg2576 Mice	Hur et al. 2018
39	Short-Chain Fatty Acids	APP23 Mice	Reuter et al 2016
40	Short-Chain Fatty Acids	APP/PS1 Mice	Xie et al. 2020
41	Statins & NSAIDs	Tg2576 Mice	Garcia-Alloza et al. 2009
42	Statins & NSAIDs	APP23 Mice	Reuter et al. 2016; Schultheiss et al. 2006
43	Statins & NSAIDs	TgSwDI Mice	Hattori et al. 2016