Table 4.

2011 MSIS criteria for periprosthetic joint infection

Major criteria (at least 1)

1. Sinus tract communicating with prosthesis

2. Pathogen is isolated by culture from 2 separate tissue or fluid samples obtained from affected joint

OR

Minor criteria (4 of the following 6)

1. Elevated ESR or CRP

2. Elevated synovial fluid WBC count

3. Elevated synovial neutrophil percentage

4. Presence of purulence in the affected joint

5. Isolation of a microorganism in one culture of periprosthetic tissue or fluid

6. Greater than five neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at x400 magnification

Adapted from Parvizi et al. (2011)

MSIS Musculoskeletal Infection Society; ESR erythrocyte sedimentation rate; WBC white blood cell