FIGURE 1.

Ivermectin targets multiple aspects of hepatocellular carcinoma (HCC) biological activities. Ivermectin dose‐dependently decreases proliferation (A) and induces apoptosis (B) in HuH6, HepB3 and SNU‐182 cells. Proliferation and apoptosis were determined after 72 h drug treatment. (C) Representative images showing SNU‐182 cell migration in the absence (control) and presence of ivermectin (20 μM). (D) Ivermectin dose‐dependently inhibits HCC cell migration. (E) Representative images showing SNU‐182 cell anchorage‐independent colony formation in agar plates in the absence (control) and presence of ivermectin (20 μM). (F) Ivermectin decreases HCC cell colony formation