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. 2022 May 14;12:60. doi: 10.1186/s13578-022-00798-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — FTO is elevated in esophageal cancer stem-like cells and is a poor prognostic factor in EC patients. A EpiQuik m6A RNA Methylation Quantification kit (Colorimetry) was used to detect the total methylation levels of mRNA extracted from normal or sphere cells; B qPCR analysis of ALKBH5 and FTO mRNA expression levels between normal and sphere cells; C Immunohistochemical analysis of FTO protein in paracancerous and cancer tissues of EC patients; D Statistical results of the FTO protein levels in paracancerous and cancer tissues of EC patients (t=11.27, P < 0.001); E Kaplan-Meier survival curve was used to analyze the overall patient survival in groups with a high and low FTO expression. Log-rank test was used to compare the median overall survival duration between the two groups (x²=15.233, P < 0.001).