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. 2022 May 14;19:111. doi: 10.1186/s12974-022-02463-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Inflammatory genes show distinct epigenetic regulation in ‘acute’, ‘tolerant’, ‘primed’ and ‘trained’ microglia. a Venn diagram of the enriched genes in acute (PL versus PP, light purple, Additional file 5), tolerized (clusters 2 and 4, dark purple, Additional file 7), primed (KO-PBS versus WT-PBS, mint, Additional file 6) and trained (KO-LPS versus WT-LPS, dark mint, Additional file 6) microglial response. b Dotplot depicting the GO terms associated with unique and overlapping gene sets of acute, tolerant, primed and trained microglia. The size of the dot represents the gene count per GO term and the color indicates the adjusted P-value. c Heat map depicting row z-scores of weighted mean differences (adjusted P value < 0.001) of ATAC peaks at loci of specific TF motifs in the indicated comparisons identified with diffTF (based on Figs. 3B, D, 4C, D; Additional files 10, 12). Only accessible TF motifs of activating, repressing and undetermined TF are displayed (not-expressed TFs were filtered out). White space indicates non-significant weighted mean differences of ATAC peaks at the given locus and/or not-expressed TFs in the indicated comparison.