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. 2022 May 14;22:189. doi: 10.1186/s12935-022-02609-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Prognostic role of INPP5B in lung adenocarcinoma. a, b KM survival curves for overall survival (a) and progression free interval (b) in LUAD patients from the Kaplan–Meier plotter online database or TCGA database. Grouping by “auto select best cutoff”. c Primary therapy outcome included complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD). Clinical benefit rate (CBR) = CR + PR + SD (PR&CR&SD = 375, PD = 71). d–f Overall survival of patients with lung adenocarcinoma after successful surgery (d), Chemotherapy (e) and Radiotherapy (f), respectively. The data were collected from the Kaplan–Meier plotter online database. Grouping by “auto select best cutoff”. g, h Univariate analysis (g) and Multivariate analysis (h) of TCGA database. HR > 1 indicates poorly prognostic; HR < 1 indicates improved OS and any characteristic crossing the line at 1 is not significant