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. 2022 May 14;22:189. doi: 10.1186/s12935-022-02609-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Pathway enrichment analysis of INPP5B. a Enrichment plots from GSEA. NES, normalized enrichment score of GSEA. p < 0.05 and FDR < 0.25 were considered statistically significant for GSEA. b KEGG signaling pathway enrichment analysis. c Gene ontology analysis included biological process (BP), molecular function (MF), and cellular component (CC). d The expression relationship between INPP5B expression and cell cycle-related genes. e Western blot analysis validation of AKT signaling pathway in LUAD cell lines. Experiments were repeated three times, and data from a representative experiment are shown