Table 5.

Univariate and multivariate Cox regression analysis of prognostic value of clinicopathological factors on tumor disease-free survival (DFS)

Variable (DFS)	Univariate cox regression analysis		Multivariate cox regression analysis
	HR (95%CI)	P	HR (95%CI)	P
Age at diagnosis		0.358	0.370(0.127–1.074)	0.067
≦50	1
> 50	1.461 (0.651–3.277)
Tumor size		0.015*	3.875(1.158–12.970)	0.028*
≦1 cm	1
> 1 cm	3.778 (1.298–10.996)
Histological grade		0.544	0.811(0.201–3.276)	0.768
I/II	1
III	1.390 (0.479–4.037)
Ki-67 index		0.164	0.723(0.090–5.784)	0.760
≦30	1
> 30	1.853 (0.778–4.414)
P53		0.152	1.056(0.317–3.514)	0.929
Positive	1
Negative	1.841 (0.799–4.242)
Basal-like marker		0.298	1.042(0.197–5.512)	0.962
Negative	1
Positive	1.681 (0.632–4.469)
Modified IHC subtype		0.277	0.606(0.199–1.842)	0.377
Basal-like	1
Luminal A	0.381(0.110–1.316)	0.127
Luminal B	0.551(0.142–2.141)	0.389
PAM50 subtype		0.006*	1.795(0.704–4.575)	0.220
Basal-like	1
Luminal A	0.290(0.082–1.026)	0.055
Luminal B	0.815(0.215–3.080)	0.762
Her-2 enriched	2.647(0.439–15.969)	0.289
ROR		0.001*	2.965(1.110–7.922)	0.030*
High	1
Medium	0.194 (0.065–0.576)	0.003
Low	0.112 (0.036–0.352)	0.000
RS		0.045*	0.885(0.420–1.867)	0.748
High	1
Medium	0.306 (0.086–1.094)	0.068
Low	0.246 (0.081–0.743)	0.013
TILs		0.067	1.295(0.383–4.380)	0.678
Low	1
High	2.353 (0.943–5.873)
Immune score		0.112	2.458(0.870–6.945)	0.090
i-weak	1
i-strong	0.352 (0.244–1.159)
Chemotherapy		0.195	0.783(0.249(2.470)	0.677
Negative	1
Postive	1.688 (0.765–3.723)
Radiotherapy		0.991	0.811(0.270–2.430)	0.708
Negative	1
Positive	0.995(0.418–2.369)

*P < 0.05