Table 6.

Univariate and multivariate Cox regression analysis of prognostic value of clinicopathological factors on tumor distant metastasis-free survival (DMFS)

Variable (DMFS)	Univariate cox regression analysis		Multivariate cox regression analysis
	HR (95%CI)	P	HR (95%CI)	P
Age at diagnosis		0.446	0.540(0.136–2.144)	0.381
≦50	1
> 50	0.659 (0.225–1.928)
Tumor size		0.152	3.188(0.716–14.205)	0.128
≦1 cm	1
> 1 cm	2.527 (0.712–8.970)
Histological grade		0.988	0.895(0.118–6.793)	0.915
I/II	1
III	1.011 (0.228–4.483)
Ki-67 index		0.904	0.472(0.025–8.760)	0.614
≦30	1
> 30	1.081 (0.305–3.834)
P53		0.528	1.006(0.206–4.913)	0.994
Positive	1
Negative	1.447 (0.459–4.562)
Basal-like marker		0.022*	5.529(1.196–25.560)	0.029*
Negative	1
Positive	3.534 (1.202–10.388)
Modified IHC subtype		0.253	0.378(0.074–1.938)	0.244
Basal-like	1
Luminal A	0.342(0.096–1.218)	0.098
Luminal B	0.000(0.000–1.734E + 229)	0.960
PAM50 subtype		0.215	1.831(0.493–6.802)	0.366
Basal-like	1
Luminal A	0.270(0.074–0.986)	0.055
Luminal B	0.209(0.035–1.252)	0.762
Her-2 enriched	0.000(0.000-)	0.289
ROR		0.077	1.542(0.425–5.592)	0.510
High	1
Medium	0.213 (0.050–0.900)	0.035
Low	0.245 (0.063–0.958)	0.043
RS		0.634	0.639(0.186–2.190)	0.476
High	1
Medium	0.492 (0.082–2.949)	0.346
Low	0.482 (0.105–2.202)	0.438
TILs		0.026*	1.801(0.390–8.311)	0.451
Low	1
High	3.385 (1.157–9.905)
Immune score		0.051	4.551(0.913–22.699)	0.065
i-weak	1
i-strong	2.752 (0.997–7.592)
Chemotherapy		0.121	1.678(0.454–6.197)	0.437
Negative	1
Positive	2.235 (0.809–6.171)
Radiotherapy		0.247	0.829(0.243–2.825)	0.764
Negative	1
Positive	1.842(0.654–5.183)

*P < 0.05