Table 2.
Details of the top 10 up/down-regulated genes
| Gene Name | Chromosome | Fold change | P value | FDR |
|---|---|---|---|---|
| Up-regulated | ||||
| CILP | 8 | 68.414 | 3.530E−04 | 0.017 |
| FHL1 | X | 50.450 | 1.184E−04 | 0.013 |
| TGFB3 | 6 | 49.868 | 9.427E−05 | 0.012 |
| ACTA2 | 1 | 46.407 | 1.783E−03 | 0.029 |
| ITGA8 | 17 | 44.424 | 4.355E−05 | 0.010 |
| MYH11 | 10 | 43.851 | 3.185E−04 | 0.017 |
| MYOCD | 10 | 30.975 | 2.123E−04 | 0.016 |
| ELN | 12 | 28.741 | 5.912E−03 | 0.046 |
| FAM150A | 5 | 24.827 | 3.258E−04 | 0.017 |
| IL1RL1 | 9 | 24.463 | 1.143E−02 | 0.062 |
| Down-regulated | ||||
| SFRP1 | 16 | 0.008 | 4.656E−05 | 0.010 |
| AKR1C14 | 17 | 0.017 | 5.622E−04 | 0.020 |
| CDH2 | 18 | 0.018 | 1.088E−08 | 5.212E−05 |
| MT2A | 19 | 0.019 | 6.261E−05 | 0.011 |
| CSCL6 | 14 | 0.022 | 1.357E−02 | 0.067 |
| SLC1A3 | 2 | 0.025 | 1.558E−05 | 0.006 |
| RBP4 | 1 | 0.025 | 1.860E−03 | 0.029 |
| LUM | 7 | 0.026 | 6.696E−04 | 0.021 |
| CCL20 | 9 | 0.029 | 1.638E−03 | 0.028 |
| IL1RN | 3 | 0.032 | 2.500E−04 | 0.016 |
FDR the adjusted P value, P value the P value of the F-statistic for gene from young and old MSCs, ACTA2 actin alpha 2, AKR1C14 aldo–keto reductase family 1 member C14, ALKAL1 ALK and LTK ligand 1, CCL20 C–C motif chemokine ligand 20, CDH2 cadherin 2, CILP cartilage intermediate layer protein, CXCL6 C-X-C motif chemokine ligand 6, ELN elastin, FHL1 four and a half LIM domains 1, IL1RL1 interleukin 1 receptor-like 1, IL1RN interleukin 1 receptor antagonist, ITGA8 integrin subunit alpha 8, LUM lumican, RBP4 retinol binding protein 4, MT2A metallothionein 2A, MYH11 myosin heavy chain 11, MYOCD myocardin, SFRP1 secreted frizzled-related protein 1, SLC1A3 solute carrier family 1 member 3, TGFB3 transforming growth factor beta 3