Fig. 3 |. Cell-based model of coagulation.

In the cell-based model of coagulation, initiation occurs on tissue factor (TF)-bearing cells, via the extrinsic pathway, and results in the activation of small amounts of thrombin. Thrombin generated on the TF-bearing cell amplifies the procoagulant response by activating additional coagulation factors and platelets. The large burst of thrombin required for formation of a fibrin clot is generated on platelet surfaces during the propagation phase. Adapted with permission from REF.³¹⁸, Wiley.