Fig. 5 |. Multifunctional roles of thrombin.
Once it is activated by the coagulation cascade, the serin protease thrombin can function in procoagulant, anticoagulant, antifibrinolytic and pro-inflammatory or anti-inflammatory pathways. PAR1, protease-activated receptor 1; TAFI, thrombin-activatable fibrinolysis inhibitor. Adapted with permission from REF.319, Wiley.