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. Author manuscript; available in PMC: 2022 May 15.
Published in final edited form as: Gynecol Oncol. 2020 Nov 7;160(1):285–294. doi: 10.1016/j.ygyno.2020.10.031

Fig. 4.

Fig. 4.

CGX-1321 promotes CD8+ T cell levels, while DKN-01 decreases MDSC-related gene signatures in ID8p53−/− model. (A) NanoString analysis of omentum samples from mice treated with CGX-1321, DKN-01, and DKN-01 + CGX-1321 (Combo) in ID8p53−/− model. Heat map depicts changes in immune pathway scores compared to vehicle/control-treated mice. (B) MDSC-related gene expression changes in ID8p53−/− model where mice were treated with vehicle/control, DKN-01, CGX-1321, or DKN-01 + CGX-1321 (Combo). Flow cytometry analysis was performed on omentums to determine the levels of infiltrating (C) cytotoxic T (Tc; CD8+) and (D) helper T (Th; CD4+) cells in omentum TME.