Skip to main content
. Author manuscript; available in PMC: 2022 May 15.
Published in final edited form as: Gynecol Oncol. 2020 Nov 7;160(1):285–294. doi: 10.1016/j.ygyno.2020.10.031

Fig. 6.

Fig. 6.

Dual inhibition of PORCN and DKK1 inhibition in ovarian cancer. CGX-1321 inhibits Wnt/β-catenin signaling by impairing Wnt ligand biosynthesis, thus decreasing tumor progression and increasing Tc cell infiltration into the TME. DKN-01 inhibits DKK1 causing a reduction in MDSC infiltration and increasing Tc cell infiltration into the TME. (Tc) cytotoxic T cell; (MDSC) myeloid-derived suppressor cell; (DKK1) dickkopf-1; (PORCN) porcupine; (Fz) frizzled receptor; (LRP5/6) low-density lipoprotein receptor-related protein 5/6; (ER) endoplasmic reticulum.