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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Clin Geriatr Med. 2022 May;38(2):193–219. doi: 10.1016/j.cger.2021.11.015

Figure 1: MMPs and ADAMTSs metalloproteases cleave type II collagen and aggrecan in the OA cartilage extracellular matrix.

Figure 1:

Chondrocytes secrete metalloproteases that degrade the cartilage extracellular matrix in OA. Studies on transgenic mice suggest that MMP13 is the key collagenase in cartilage, while ADAMTS5 is the main ‘aggrecanase’.