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Osteocyte-intrinsic inhibition of MMP13 or TGFβ signaling is sufficient to mimic several hallmarks of human osteoarthritis
| Human OA | MMP13ocy−/− | TβRIIocy−/− | |
|---|---|---|---|
| Cartilage Degeneration | ✓ | ✓ | ✓ |
| Subchondral Sclerosis | ✓ | ✓ | ✓ |
| Thickened Subchondral Plate | ✓ | ✓ | ✓ |
| Collagen Disorganization | ✓ | ✓ | |
| Mineral Heterogeneity | ✓ | ✓ | |
| Degenerated Osteocyte LCN | ✓ | ✓ | ✓ |
| Impaired Mechanosensitivity | ✓ | ||
| Altered TGFβ signaling | ✓ | ✓ | |
| Altered MMP13 activity | ✓ | ✓ | ✓ |
