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. Author manuscript; available in PMC: 2023 Apr 29.
Published in final edited form as: Science. 2022 Apr 28;376(6592):527–532. doi: 10.1126/science.abo4282

Fig. 1. Introduction to scaffold hopping and single-atom skeletal editing.

Fig. 1.

(A) Schematic representation of the disconnect between design and synthesis in molecular optimization. (B) Selected examples of scaffold hopping in medicinal chemistry. HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; Me, methyl group; COX-2, cyclooxygenase-2. (C) Single-atom skeletal editing for heterocycle interconversion. (D) Carbon deletion of azaarenes delineated in this work.