Fig. 3.

: Screening of active compound classes against SARS-CoV-2 lentiviral pseudoviruses with different SARS-CoV-2 spike variants. Compounds interfering with nucleic acid synthesis (A), G-protein coupled receptor antagonists (B), inhibitors of microtubule polymerization (C) and compounds with different mode of actions (D). All data were normalized to DMSO (shown in D). SARS-CoV-2 spike D614G variant shown in green, Alpha in yellow, Beta in blue, Delta in pink and Omicron in grey. Data shown is based on the average and standard deviation of three independent experiments. Compound structures are given in Supporting Fig. 1.