Fig. 5.

: Toxicity and virostatic effect of different endocytosis inhibitors. Toxicity (shown as cell viability (%), grey) was tested using the CaCo2 cell line and virostatic activity (green) was analyzed using the Omicron SARS-CoV-2 lentiviral pseudovirus. All compounds were tested at 10 µM. Five different proteins of the endocytosis pathway were analyzed. PI3K using Copanlisib, Pictilisib and YM201636; Dynamin using Mdivi1; PDE using PDE10-IN-1 and Sildenafil; ß-arrestin using Pirenzepine and Levetimidine; Calmodulin using A-7, Zaldaride, Dexniguldipine (also a p-gp efflux pump inhibitor). Data shown is based on the average and standard deviation of three independent experiments.