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. 2022 May 16;39(9):110904. doi: 10.1016/j.celrep.2022.110904

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Higher β-coronavirus cross-reactive IgG titers are correlated with COVID-19 severity

(A–H) Graphs compare the level of IgG binding to spike proteins of (A and E) SARS1, (B and F) OC43, (C and G) NL63, and (D and H) 229E coronavirus as assessed by CBA and detected by flow cytometry. Graphs (A–D) compare the level of anti-spike IgG in SARS-CoV-2-naive versus -convalescent donors. Graphs (E–H) compare the levels of anti-spike IgG among donor groups separated by SARS-CoV-2 status and COVID-19 severity scores, n = 13 mild, 15 severe. The SEMs of N = 3 experiments are shown.