Figure 5.

SARS-CoV-2 convalescent IgG from mild and severe donors differentially target seasonal CoV-conserved and non-conserved SARS-CoV-2 spike protein immunodominant epitopes

(A–G) Graphs compare the levels of IgG-binding to (A) RBD, (B) S2′FP, (C) HR2, (D) 5′fHR2, (E) CTD1, (F) CTD2, and (G) S1/S2 regions in CoV-2⁺ convalescent donors as detected by luminescent ELISA versus severity scores (left) or total CBA anti-spike IgG levels (right). Inverse, positive, or no correlation is indicated by blue, red, or gray, respectively. n = 28; the SEMs of N = 3 experiments are graphed.