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. 2022 May 16;13:30. doi: 10.1007/s12672-022-00494-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — KLF14 targets ITGB1 and inhibits the development of cervical cancer through the PI3K/AKT signalling pathway. A Four groups were established: Lv-control (ITGB1), Lv-ITGB1, Lv-ITGB1 + Lv-control (KLF14) and Lv-ITGB1 + Lv-KLF14 (the KLF14 overexpression lentivirus and its negative control lentivirus were transfected into SiHa cells transfected with Lv-ITGB1). When ITGB1 was overexpressed, compared to the Lv-control (ITGB1) group, the Western blot results showed that the expression of PDK1, AKT and p-AKT was upregulated, while Bax was downregulated. However, when Lv-KLF14 and Lv-ITGB1 were cotransfected, the expression of PDK1, AKT and p-AKT was downregulated compared to that in the Lv-ITGB1 + Lv-control (KLF14) group, while Bax was upregulated. B. Two groups were established: Lv-KLF14 + Lv-control (ITGB1) and Lv-KLF14 + Lv-ITGB1 (the ITGB1 overexpression lentivirus and its negative control lentivirus were transfected into SiHa cells transfected with Lv-KLF14). For Lv-KLF14 + Lv-control (ITGB1) and Lv-KLF14 + Lv-ITGB1, the Western blot results showed that the expression of PDK1, AKT and p-AKT in the Lv-KLF14 + Lv-ITGB1 group was upregulated compared to that in the Lv-KLF14 + Lv-control (ITGB1) group, while Bax was downregulated. (*P < 0.05, **P < 0.01, ***P < 0.001)