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. 2022 May 2;9:809985. doi: 10.3389/fmolb.2022.809985

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Copyright © 2022 Santos, Fidalgo, Varanda, Soares, Almeida, Martins, Mendes, Oliveira and Santos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of tRNA deregulation in tumor initiation. (A) All animals inoculated with BEAS-2B cells harboring the recombinant tRNA^Ser(AGA) developed a tumor, whereas only 50% of the mice had BEAS-2B Mock tumors of small size. (B) Macroscopy imagens of Mock and tRNA^Ser(AGA)-derived tumors inoculated in the same animal (C) H&E of Mock and tRNA^Ser(AGA)-derived tumors. Upper part, Digitalization of whole tumors with indication (∼3.3x amplification) of Skeletal Muscle invasion and Necrotic areas. Bottom part. 20x amplification of indicated tumoral areas.