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. 2022 May 2;13:840844. doi: 10.3389/fimmu.2022.840844

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Copyright © 2022 Zhuang and Long

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD19.NK-CAR overcomes NKG2A-mediated inhibition. (A) Diagram of CAR stimulation by antibodies immobilized on beads. (B) Western blot detecting activation signals in lysates of CARs-expressing NKL cells after stimulation by beads. Untransfected NKL cells (N) were included as control. The indicated antibodies were pre-bound to beads, and then incubated with CAR-NK cells for 10 min. Cell lysates were probed for the indicated signaling molecules. (C) Western blot quantification of the pErk/total-Erk and pPLCγ1/total-PLCγ1 ratios (n=2).