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. 2022 May 2;12:882661. doi: 10.3389/fcimb.2022.882661

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Copyright © 2022 Gu, Pan, Yuan, Zhou, Chen, Wang, Fang, Hu, Xie and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolomic alternations associated with clinical symptoms of COVID-19 compared with healthy control. (A) PCA analysis. (B) OPLS-DA analysis. (C) Permutation analysis. Metabolomic alternations between severe group and healthy control. (D) PCA analysis. (E) OPLS-DA analysis. (F) Permutation analysis. Metabolomic alternations between critical group and healthy control. (G) PCA analysis. (H) OPLS-DA analysis. (I) Permutation analysis.