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. 2022 May 2;13:851342. doi: 10.3389/fphar.2022.851342

FIGURE 2.

FIGURE 2

Artemether improves hepatic steatosis and liver injury in NASH mice induced by a HFD. (A) Experiment design was divided into three groups: chow diet group (Chow), high-fat diet group (HFD), and high-fat diet combined with the artemether treatment group (Art): 20 mg/kg BW intraperitoneally once a week for 7 weeks (n = 6). (B) Body weight change after dosing. (C) Liver weight. (D) Serum ALT and AST levels. (E) Serum TG and TC levels. (F) TG and TC concentrations in the liver. (G) From left to right, H&E staining of the liver (scale bar, 50 μM) and oil red O staining of the liver (scale bar: 50 μM). The Chow group vs. the HFD group: # p < 0.05, ## p < 0.01, and ### p < 0.001. The Art group compared with the HFD group: *p < 0.05, **p < 0.01, and ***p < 0.001.