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. 2022 May 2;13:851342. doi: 10.3389/fphar.2022.851342

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Copyright © 2022 Xu, He, Huang, Zhang, Ren, Asakiya, Li and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of artemether treatment on the liver lipid metabolic pathway in NASH mice induced by an HFD. (A) KEGG pathway enrichment of the differential gene. (B) Heat map of the free fatty acid metabolism-related gene. (C,D) Real-time PCR analysis of lipid synthesis-related genes (C) and lipolysis-related genes (D) in the liver. (E–H) Expression and quantification analysis of lipid synthesis-related protein (E,F) and lipid breakdown-related protein (G,H) in the liver were detected by western blot. *p < 0.05, **p < 0.01, and ***p < 0.001.