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. 2022 May 2;13:851342. doi: 10.3389/fphar.2022.851342

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Copyright © 2022 Xu, He, Huang, Zhang, Ren, Asakiya, Li and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Artemether improves lipid metabolism induced by oleic and palmitic acids in HepG2 cells. (A,B) Real-time PCR analysis of lipid synthesis-related genes (A) and lipolysis-related genes (B) in the HepG2 cells. (C) Western blot was used to detect the expression of lipid synthesis-related proteins in HepG2 cells. (D) Quantitative plots of the protein expression associated with lipid synthesis. (E) Western blot detected the expression of lipolytic protein in HepG2 cells (n = 3). (F) Quantitative plots of lipid breakdown-related protein expression. Con vs. OA-PA: ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001. OA-PA vs. Art-L and Art-H: *p < 0.05, **p < 0.01, and ***p < 0.001.