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. 2022 May 2;13:846541. doi: 10.3389/fphar.2022.846541

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Copyright © 2022 Li, Fan, Yang, Li, Zhang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNLA inhibited NLRP3/GSDMD signaling pathway activation. After DNLA treatment for 14days, the protein expressions of GSDMD and NLRP3 in hippocampus CA1 were measured by immunofluorescence staining. Scale bar = 50 μm (A). The green color indicated caspase-1-positive cells, and red color exhibited GSDMD-N-positive cells. Quantitative analysis of protein density of GSDMD-N and caspase-1 (B). Protein expressions of GSDMD-N, caspase-1, NLRP3, and ASC in the hippocampus were measured by Western blotting assay (C). Quantitative analysis of the expression of GSDMD-N, caspase-1, NLRP3, and ASC; the reference value of the protein/GAPDH was the ratio of the control group (D). Data were expressed as mean ± SEM, n = 3–4. *p < 0.05 compared with the control group; ^# p < 0.05 compared with the LPS-treated group.