Table 4.
Clinical trials of exosomes in various cancer studies.
| Sl no | - NCT number | Title of project | Condition | - Clinical Trial Phase | References |
| 1. | NCT04939324 | Molecular Profiling of Exosomes in tumour-draining Vein of Early-staged Lung Cancer (ExOnSite-Pro) | Lung Cancer Exosomes Non Small Cell Lung Cancer | Pre-clinical phase | [218] |
| 2. | NCT03542253 | Combined Diagnosis of CT and Exosome in Early Lung Cancer | Early Lung Cancer | Pre-clinical phase | [219] |
| 3. | NCT03821909 | Acquisition of Portal Venous CTCs and Exosomes From Patients With Pancreatic Cancer by EUS | Pancreatic Cancer | Pre-clinical phase | [220] |
| 4. | NCT01779583 | Circulating Exosomes as Potential Prognostic And Predictive Biomarkers In Advanced Gastric Cancer Patients ("EXO-PPP Study") | Gastric Cancer | Pre-clinical phase | [100] |
| 5. | NCT01344109 | A Pilot Study of tumour-derived Exosomes as Diagnostic and Prognostic Markers in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy | Breast Neoplasms | Pre-clinical phase | [221] |
| 6. | NCT02393703 | Interrogation of Exosome-mediated Intercellular signalling in Patients With Pancreatic Cancer | Pancreatic Cancer Benign Pancreatic Disease | Pre-clinical phase | [222] |
| 7. | NCT02702856 | Clinical Validation of a Urinary Exosome Gene Signature in Men Presenting for Suspicion of Prostate Cancer | Prostate cancer | Pre-clinical phase | [223] |
| 8. | NCT02147418 | Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma | Oropharyngeal Cancer | Pre-clinical phase | [224] |
| 9. | NCT03738319 | Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer | High Grade Serous Carcinoma•Ovarian Cancer •Exosomes •Prognosis •Early Diagnosis | Pre-clinical phase | [225] |
| 10. | NCT01668849 | Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With ChemoradiationTreatment of Head and Neck Cancer | Dietary Supplement: Grape extract •Drug: Lortab, Fentanyl patch, mouthwash | Pre-clinical phase | [226] |
| 11. | NCT02890849 | Clinical Research for the Consistency Analysis of PD-L1 in Cancer Tissue and Plasma Exosome | •NSCLC | Pre-clinical phase | [227] |
| 12. | NCT04394572 | Identification of New Diagnostic ProteinMarkers for Colorectal Cancer | Colorectal Cancer | Pre-clinical phase | [228] |
| 13. | NCT03109873 | Metformin Hydrochloride in Affecting Cytokinesand Exosomes in Patients With Head and Neck Cancer | •Larynx •Lip •Oral Cavity •Pharynx | Early Phase 1 | [229] |
| 14. | NCT01159288 | Trial of a Vaccination WithTumor Antigenloaded Dendritic Cell-derived Exosomes | •Non Small Cell Lung Cancer | Phase 2 | [195] |
| 15. | NCT04960956 | Glycosylation of Exosomes in Prostate and Urothelial Carcinoma | •Prostate Cancer •Urothelial Carcinoma | Pre-clinical phase | [230] |
| 16. | NCT04288141 | A Study to Measure the Expression of the HER2-HER3 Dimer in Tumour and Blood(Exosomes) Samples From Patients With HER2 Positive Breast Cancer Receiving HER2Targeted Therapies | •HER2-positive Breast Cancer | Pre-clinical phase | [231] |
| 17. | NCT03974204 | Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicionof Leptomeningeal Metastasis | Breast Cancer •Leptomeningeal Metastasis | Pre-clinical phase | [232] |
| 18. | NCT04529915 | Multicenter Clinical Research for Early Diagnosis of Lung Cancer Using Blood Plasma Derived Exosome | Lung Cancer | Pre-clinical phase | [233] |
| 19. | NCT03032913 | Diagnostic Accuracy of Circulating tumour Cells (CTCs) and Onco-exosome Quantification in the Diagnosis of Pancreatic Cancer - PANCCTC | •Pancreatic Ductal Adenocarcinoma (PDAC) | Pre-clinical phase | [234] |
| 20. | NCT01294072 | Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal andColon Cancer Tissue | •Colon Cancer | Phase 1 | [235] |
| 21. | NCT03874559 | Exosomes in Rectal Cancer | Rectal cancer | Pre-clinical phase | [236] |
| 22. | NCT04167722 | How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages(Exosomes) From Fat Tissue in Lean and Obese Patients | Prostate Cancer •Obesity | Pre-clinical phase | [237] |
| 23. | NCT02869685 | Clinical Research for the Consistency Analysis of PD-L1 in Lung Cancer Tissue and Plasma Exosome Before and After Radiotherapy | •NSCLC | Pre-clinical phase | [227] |
| 24. | NCT04629079 | Improving the Early Detection of Lung Cancer by Combining Exosomal Analysis of Hypoxia With Standard of Care Imaging | •Lung Cancer | Pre-clinical phase | [238] |
| 25. | NCT04227886 | Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer | •Rectal Neoplasm MalignantCarcinoma •Chemoradiotherapy •Neoadjuvant Therapy •Predictive Biomarkers •Adenocarcinoma | Pre-clinical phase | [99] |
| 26. | NCT03581435 | A Study of Circulating Exosome Proteomics In Gallbladder Carcinoma Patients | •Proteinosis •Gallbladder Carcinoma | Pre-clinical phase | [239] |
| 27. | NCT03102268 | ncRNAs in Exosomes of Cholangiocarcinoma | •Cholangiocarcinoma •Benign Biliary stricture | Pre-clinical phase | [240] |
| 28. | NCT03608631 | iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation | KRAS NP_004976.2:p.G12D •Metastatic Pancreatic Adenocarcinoma •Pancreatic Ductal Adenocarcinoma •Stage IV Pancreatic Cancer AJCC v8 | Phase 1 | [241] |
| 29. | NCT04053855 | Evaluation of Urinary Exosomes Presence From Clear Cell Renal CellCarcinoma | Clear Cell Renal Cell Carcinoma | Pre-clinical phase | [242] |
| 30. | NCT04453046 | Hemopurifier Plus Pembrolizumab in Head and Neck Cancer | •Squamous Cell Carcinoma of the Head and Neck | Pre-clinical phase | [243] |
| 31. | NCT05218759 | Exosomes Detection for the Prediction of theEfficacy and Adverse Reactions of Anlotinib in Patients With Advanced NSCLC | Non-Small Cell Lung Cancer | Pre-clinical phase | [244] |
| 32. | NCT03811600 | Exosomes Implication in PD1-PD-L1 Activation in OSAS | Sleep Apnea syndromes,Obstructive •Cancer | Pre-clinical phase | [245] |
| 33. | NCT04499794 | The Study of Exosome EML4-ALK Fusion in NSCLC Clinical Diagnosis and Dynamic Monitoring | Untreated Advanced NSCLC Patients •FISH Identified ALK FusionPositive or Negative | Pre-clinical phase | [246] |
| 34. | NCT03830619 | Serum Exosomal Long Noncoding RNAs as Potential Biomarkers for Lung Cancer Diagnosis | Lung Cancer (Diagnosis | Pre-clinical phase | [98] |
| 35. | NCT04427475 | Prediction of Immunotherapeutic Effect of Advanced Non-small Cell Lung Cancer | NSCLC Patients | Pre-clinical phase | [247] |
| 36. | NCT04530890 | Interest of Circulating tumour DNA in Digestive and gynaecologic/Breast Cancer | •Breast Cancer •Digestive Cancer •gynaecologic Cancer •Circulating tumour DNA •Exosomes | Pre-clinical phase | [248] |
| 37. | NCT05101655 | Construction of Microfluidic Exosome Chip for Diagnosis of Lung Metastasis of Osteosarcoma | •Osteosarcoma •Pulmonary Metastases | Pre-clinical phase | [249] |
| 38. | NCT03800121 | Study of Exosomes in Monitoring Patients With Sarcoma (EXOSARC) | •Sarcoma | Pre-clinical phase | [250] |
| 39. | NCT03108677 | Circulating Exosome RNA in Lung Metastasesof Primary High-Grade Osteosarcoma | Lung Metastases •Osteosarcoma | Pre-clinical phase | [251] |
| 40. | NCT03895216 | Identification and Characterization of Predictive Factors of Onset of Bone Metastases in CancerPatients | •Bone Metastases | Pre-clinical phase | [252] |
| 41. | NCT04720599 | Clinical Evaluation of ExoDxProstate(IntelliScore) in Men Presenting for Initial Prostate Biopsy | Urologic Cancer | Pre-clinical phase | [253] |
| 42. | NCT02310451 | Study of Molecular Mechanisms Implicated in the Pathogenesis of Melanoma.Role of Exosomes | •Metastatic Melanoma • | Pre-clinical phase | [254] |
| 43. | NCT04747574 | Evaluation of the Safety of CD24-Exosomes inPatients With COVID-19 Infection | SARS-CoV-2 | Phase 1 - | [255] |
| 44. | NCT04636788 | Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human PancreaticCancer | •Pancreas Adenocarcinoma | Pre-clinical phase | [256] |
| 45. | NCT04356300 | Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection | •Multiple Organ Failure | Pre-clinical phase | [257] |
| 46. | NCT03985696 | Exosomes and Immunotherapy in Non-HodgkinB-cell Lymphomas | Lymphoma, B-cell, Aggressive Non-Hodgkin (B-NHL) | Pre-clinical phase | [258] |
| 47. | NCT04852653 | A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Treatment Response Assessment in Rectal Cancer | Multiple Organ Failure | Pre-clinical phase | [259] |
| 48. | NCT04357717 | ExoDx Prostate Evaluation in Prior NegativeProstate Biopsy Setting | •Prostate Cancer | Pre-clinical phase | [260] |
| 49. | NCT04653740 | Omic Technologies to Track Resistance to Palbociclib in Metastatic Breast Cancer | Advanced Breast Cancer | Pre-clinical phase | [261] |
| 50. | NCT04948437 | Urinary Exosomal Biomarkers of Thyroglobulin and Galectin-3 for Prognosis and Follow-up in Patients of Thyroid Cancer | Thyroid Cancer •Papillary Thyroid Cancer •Follicular Thyroid Cancer | Pre-clinical phase | [101] |
| 51. | NCT03488134 | Predicting Prognosis and Recurrence of Thyroid Cancer Via New Biomarkers, Urinary Exosomal Thyroglobulin and Galectin-3 | •Thyroid Cancer | Pre-clinical phase | [262] |
| 52. | NCT04298398 | Impact of Group Psychological Interventions on Extracellular Vesicles in People Who HadCancer | Cancer | Pre-clinical phase | [263] |
| 53. | NCT02862470 | Anaplastic Thyroid Cancer and FollicularThyroid Cancer-derived Exosomal AnalysisVia Treatment of Lovastatin and Vildagliptin and Pilot Prognostic Study Via Urine Exosomal Biological Markers in Thyroid Cancer Patients | Thyroid Cancer | Pre-clinical phase | [264] |
| 54. | NCT05192694 | Evaluation of Fapi-pet in Prostate Cancer. | •Prostate Cancer | Pre-clinical phase | [265] |
| 55. | NCT03493984 | Plant Exosomes and Patients Diagnosed With Polycystic Ovary Syndrome (PCOS) 17 | •Other: Ginger exosomes •Other: Aloe exosomes •Other: Placebo | Pre-clinical phase | [266] |
| 56. | NCT03228277 | Olmutinib Trial in T790M (+) NSCLC Patients Detected by Liquid Biopsy Using BALFExtracellular Vesicular DNA | Non Small Cell Lung Cancer | •Drug: Olmutinib Phase: Phase 2 | [267] |
| 57. | NCT04182893 | Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules | Pulmonary Nodules | Pre-clinical phase | [268] |