Fig. 5.

Acute and sustained increase in qEEG gamma induction in healthy elderly subjects receiving multiple doses of fosgonimeton at 20 mg (SC, OD, 9 days). qEEG assessments were conducted at predose, and 1 hour and 3 hours postdose, on days 1, 4, and 8. The heat maps illustrate the average change in relative qEEG power from baseline (day 1 predose) to each qEEG recording after treatment start (change from study baseline ratio). Only gamma power shown; fosgonimeton did not induce consistent and substantial changes in any other waveform. OD, once daily; qEEG, quantitative electroencephalogram; SC, subcutaneous.