Table 1.

Inhibitory activities (IC₅₀ nM) of AChE and BuChE and selectivity index of novel tacrine-like compounds

Compounds	IC50 (nM)		Ratio of BuChE/AChE IC50	Multi-targeted ligand	Ref
	AChE	BuChE
Tacrine	174.00	32.00	5.40	—	[151]
5	150.00	36.00	0.24	BACE1 inhibition, Neuroprotection against glutamate toxicity	[145]
6	49.00	93280.00	1903.67	Neuroprotection and Aβ aggregation inhibitory activities	[146]
7	3.90	24.30	6.23	Inhibition of Aβ 42 self-aggregation and fibril formation, Antioxidant activity, Neuroprotection	[147]
8a	580.00	>66050	>113.88	—	[148]
8b	440.00	>61020	>138.68	—
9	3050.00	3190.00	1.05	Moderate-to-potent calcium channel blockers	[149]
10	2.20	4.93	2.24	—	[150]
11	0.12	361.52	3012.67	HDAC inhibition, Cu2+ chelating properties	[151]
12	26.00	9.00	0.35	—	[152]
13	259.00	–	–	Antioxidant activity	[141]
14	22.15	6.96	0.31	—	[142]
15	10.00	57.00	5.70	Antioxidant activity	[143]
16a	13.00	21.00	1.62	—	[144]
16b	2.00	110.00	55.00	—
17	33.40	62.00	1.86	NMDA receptors inhibition	[153]