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. 2022 May 9;19:550–568. doi: 10.1016/j.bioactmat.2022.04.029

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Assessment of motor functional recovery and axon regeneration of spinal cord transected rats after treatment by BMSC-encapsulated hydrogels at 56 days post surgery. (a1) Functional recovery evaluated through Basso-Beattie-Bresnahan (BBB) score. (a2) Analysis of % of animals with a BBB score ≥7 on day 28 and 56 post surgery, suggesting the function restoration in the presence of BMSCs–containing ROS responsive hydrogel. (b) NF200 (neurofilament-200, marker of axon) and GFAP double immunofluorescence staining of nerve fibers and glial scars. The magnified images show the specific areas in the white boxes, and nerve structure in rostral and caudal regions. Quantitative analysis of (c1) NF200 positive and (c2) GFAP positive areas, showing a better neuron preservation and axon regeneration effect of BMSCs-encapsulated ROS-scavenging hydrogel. (d) Tuj-1 (tubulin-III, marker of neurogenesis) and MAP-2 (microtubule-associated protein-2, marker of mature neurons) immunofluorescence double staining images of nerve structure. (e) The magnified images show specific areas in the white boxes. The dashed lines outline the 2 mm transection. *p < 0.05, **p < 0.01, ***p < 0.001.

Fig. 7 — Assessment of motor functional recovery and axon regeneration of spinal cord transected rats after treatment by BMSC-encapsulated hydrogels at 56 days post surgery. (a1) Functional recovery evaluated through Basso-Beattie-Bresnahan (BBB) score. (a2) Analysis of % of animals with a BBB score ≥7 on day 28 and 56 post surgery, suggesting the function restoration in the presence of BMSCs–containing ROS responsive hydrogel. (b) NF200 (neurofilament-200, marker of axon) and GFAP double immunofluorescence staining of nerve fibers and glial scars. The magnified images show the specific areas in the white boxes, and nerve structure in rostral and caudal regions. Quantitative analysis of (c1) NF200 positive and (c2) GFAP positive areas, showing a better neuron preservation and axon regeneration effect of BMSCs-encapsulated ROS-scavenging hydrogel. (d) Tuj-1 (tubulin-III, marker of neurogenesis) and MAP-2 (microtubule-associated protein-2, marker of mature neurons) immunofluorescence double staining images of nerve structure. (e) The magnified images show specific areas in the white boxes. The dashed lines outline the 2 mm transection. *p < 0.05, **p < 0.01, ***p < 0.001.