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. 2022 Apr 22;25(5):104279. doi: 10.1016/j.isci.2022.104279

Figure 2.

Figure 2

miR-25 promotes the intracellular survival of BCG and Mtb

(A–D) THP-1 cells pre-transfected with control mimic, miR-25 mimic, control inhibitor or miR-25 inhibitor were infected with BCG or H37Rv for a specified period of time, and then CFU detectionwas performed.

(E) WT or miR-25−/− mice were infected with BCG for 7 days, and the lungs, livers and spleens were subjected to CFU assay, (F) lungs were treated with H&E staining, scale bar, 200 μm; the WT or miR-25−/− mice were infected with PBS for 7 days, (F) H&E staining in lungs of WT or miR-25−/−mice, scale bar, 200 μm. Data are presented as means ± SD . ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.005, ns, not significant.