Table 1.
Logistic regression analysis of the association of therapeutic modalities with acute and subchronic complications for older men aged ≥80 years with high-risk prostate adenocarcinoma.
| RP | IMRT + long-term HT | IMRT vs RP (ref.) | ||||
|---|---|---|---|---|---|---|
| N = 277, % | N = 382, % | adjusted odds ratios* (95% CI) | P value | |||
| Days 1–90 after Tx | ||||||
| BPH symptoms | 264 (88.81) | 376 (98.43) | 3.09 (1.21, 7.87) | .022 | ||
| Impotence | 21 (7.58) | 31 (8.12) | 1.17 (1.03, 1.35) | .035 | ||
| UI | 99 (35.74) | 76 (19.90) | 0.45 (0.32, 0.63) | .007 | ||
| Urethral strictures | 12 (4.33) | 13 (3.40) | 1.18 (0.34, 1.76) | .391 | ||
| Hernias | 30 (10.83) | 16 (4.19) | 0.36 (0.19, 0.68) | .017 | ||
| Days 91–365 after Tx | ||||||
| BPH symptoms | 128 (46.21) | 332 (86.91) | 6.05 (4.53, 9.72) | .009 | ||
| Impotence | 9 (3.25) | 26 (6.81) | 1.19 (1.01, 2.81) | .045 | ||
| UI | 70 (25.27) | 72 (18.85) | 0.69 (0.48, 0.97) | .048 | ||
| Urethral strictures | 6 (2.17) | 6 (1.57) | 1.21 (0.80, 7.25) | .262 | ||
| Hernias | 28 (10.11) | 13 (3.40) | 0.32 (0.16, 0.62) | .021 | ||
| At 2 years after Tx | ||||||
| BPH symptoms | 113 (40.79) | 310 (81.15) | 6.35 (5.02, 9.76) | .003 | ||
| Impotence | 11 (3.97) | 20 (5.24) | 1.50 (0.70, 3.19) | .359 | ||
| UI | 72 (25.99) | 68 (17.80) | 0.62 (0.43, 0.92) | .034 | ||
| Urethral strictures | 8 (2.89) | 7 (1.83) | 1.65 (0.38, 8.29) | .184 | ||
| Hernias | 30 (10.83) | 13 (3.40) | 0.29 (0.15, 0.58) | .005 | ||
*Multivariable model with adjustment of covariates: Age, year of diagnosis, CCI scores, myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, chronic pulmonary disease, diabetes, hypertension, income, hospital area, hospital level, clinical T stages, Gleason score, grade, preoperative PSA, and D’Amico risk classification. Least square mean difference for odds ratio for binary variables via fitting generalized liner model with stratification of matched pairs.
RP, radical prostatectomy; IMRT, intensity-modulated radiation therapy; CI, confidence interval; UI, urinary incontinence; Ref., reference group; N, number; BPH, benign prostatic hyperplasia; HT, hormone therapy; Tx, treatment.