Table 2.

Logistic regression analysis of the association of therapeutic modalities with late complications for older men aged ≥80 years with high-risk prostate adenocarcinoma.

	RP	IMRT+ long-term HT	IMRT vs RP (ref.)
	N = 277, %	N = 382, %	adjusted odds ratios* (95% CI)		P value
At 3 years after Tx
BPH symptoms	105 (37.91)	276 (72.25)	5.68 (3.91, 8.25)	.021
Impotence	11 (3.97)	15 (3.93)	1.47 (0.71, 3.08)	.252
UI	60 (21.66)	50 (13.09)	0.69 (0.46, 0.84)	.007
Urethral strictures	5 (1.81)	5 (1.31)	1.97 (0.87, 8.57)	.237
Hernias	20 (7.22)	9 (2.36)	0.32 (0.15, 0.71)	.014
At 4 years after Tx
BPH symptoms	58 (20.94)	142 (37.17)	5.19 (3.52, 9.21)	.009
Impotence	6 (2.17)	10 (2.61)	1.26 (0.73, 5.47)	.121
UI	36 (13.00)	26 (6.81)	0.51 (0.29, 0.89)	.013
Urethral strictures	3 (1.08)	3 (0.79)	1.04 (0.57, 2.23)	.321
Hernias	10 (3.61)	3 (0.79)	0.23 (0.16, 0.85)	.005
At 5 years after Tx
BPH symptoms	46 (17.69)	113 (29.58)	4.15 (2.82, 7.37)	.007
Impotence	5 (1.81)	8 (2.09)	1.02 (0.72, 2.11)	.118
UI	29 (10.47)	21 (5.50)	0.50 (0.28, 0.88)	.008
Urethral strictures	2 (0.72)	2 (0.52)	1.01 (0.55, 2.01)	.230
Hernias	8 (2.89)	2 (0.52)	0.21 (0.11, 0.82)	.002

^*Multivariable model with adjustment of covariates: Age, year of diagnosis, CCI scores, myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, chronic pulmonary disease, diabetes, hypertension, income, hospital area, hospital level, clinical T stages, Gleason score, grade, preoperative PSA, and D’Amico risk classification. Least square mean difference for odds ratio for binary variables via fitting generalized linear model with stratification of matched pairs.

RP, radical prostatectomy; IMRT, intensity-modulated radiation therapy; CI, confidence interval; UI, urinary incontinence; Ref., reference group; N, number; BPH, benign prostatic hyperplasia; Tx, treatment.