TABLE 1.
Changes in cough frequency in two participants with chronic cough
| Intervention |
Cough frequency before intervention# (coughs·h−1) |
Cough frequency after intervention# (coughs·h−1) |
Proportional change % | p-value | Proportion of time the effect size is inaccurate % (24-h period) | Proportion of time the direction of the effect is reversed % (24-h period) |
| Case 1: participant with chronic cough | ||||||
| Gabapentin | 21.31 | 13.72 | −35 | 0.00002 | 57 | 8 |
| Omeprazole | 9.70 | 3.98 | −59 | 0.000002 | 62 | 4 |
| Case 2: chronic smoker | ||||||
| Smoking stopped | 1.53 | 0.58 | −62 | 0.0009 | 68 | 21 |
| Smoking restarted | 0.70 | 1.2 | +71 | 0.003 | 43 | 14 |
| Smoking stopped | 1.61 | 0.94 | −42 | 0.008 | 50 | 23 |
#: the interventions were different for both participants – treatment with gabapentin and omeprazole in case 1, and smoking cessation/relapses in case 2.